Liverpool kicked off the new year three points clear atop the English Premier League standings with a 4-2 victory over Newcastle United.
Bukayo Saka scored either side of halftime as Arsenal crushed second-bottom Burnley 5-0.
Eddie Howe's side were ruthless in boosting their Champions League qualification hopes while 19th-placed Leicester became the first side in English Football League history to suffer eight successive home league defeats without scoring.
IMAGES from the English Premier League matches played on Saturday.
Jose Mourinho's side top Group G with a maximum nine points, three clear of second-placed Slavia.
A summary of Sunday's action in the Premier League.
Arsenal snapped a season-long jinx against Newcastle United with a nervy 1-0 win in their last Premier League home game on Sunday.
Aston Villa striker Marcus Rashford scored twice in a 3-0 defeat of second-tier Preston North End in their FA Cup quarter-final at Deepdale on Sunday to earn a Wembley semi-final against fellow Premier League team Crystal Palace.
Champions Manchester City struggled in this campaign and sit sixth in the table after winning only two of their last 10 league matches.
'The boys will be pleased not to lose but also definitely not happy we didn't win.'
Manchester City came from behind to beat Club Brugge 3-1 and secure their place in the Champions League playoffs
Liverpool reclaimed top spot in the Premier League with a 3-1 win over Burnley at Anfield on Saturday, but they were made to battle hard by a brave visiting side.
Brazilian Casemiro struck late to send Manchester United into the FA Cup quarter-finals with a 1-0 victory over Nottingham Forest as teenagers Jayden Danns and Lewis Koumas inspired Liverpool to a 3-0 win over Southampton on Wednesday.
Liverpool cruised into the fifth round of the FA Cup with a 5-2 rout of Championship side Norwich City on Sunday, to kick off Juergen Klopp's long goodbye at Anfield.
With a game in hand, Hansi Flick's Barca are top on 66 points, three ahead Real in second
England debutant Myles Lewis-Skelly got new coach Thomas Tuchel's reign up and running as the 18-year-old scored the first goal in a 2-0 home victory against Albania in their World Cup qualifying Group K opener on Friday.
A summary of Wednesday's Champions League first leg quarter-finals between Barcelona and Dortmund and Real Madrid, and Paris St Germain and Aston Villa.
Brazil, who are fifth in the CONMEBOL table with 18 points from 12 games, host Colombia on March 21 and visit Argentina five days later in a match that could see Neymar come up against former Barcelona and Paris St Germain teammate Lionel Messi.
Arsenal moved to 50 points from 24 games.
Van Dijk was sent off for fouling Alexander Isak during the first half and appeared to remonstrate with referee John Brooks before walking off the pitch.
Liverpool moved back to the top of the Premier League with a 2-0 victory at struggling Burnley
Third-placed Aston Villa are the surprise package of the season and Unai Emery's side face relegation-threatened Burnley while fifth-placed Spurs host a resurgent Bournemouth who have 19 points from their last seven games.
West Ham beat Premier League strugglers Leicester City 2-0 at the London Stadium on Thursday thanks to an early strike from Tomas Soucek on his 30th birthday and an own goal just before halftime.
Liverpool snatched three points with a wild 1-0 victory over relegation-threatened Nottingham Forest.
Graham Potter is in talks to replace Lopetegui, according to British media reports, and the former Chelsea and Brighton & Hove Albion manager is expected to take charge of West Ham for their FA Cup third-round game at Aston Villa on Friday.
Athletic Bilbao beat Barcelona 4-2 at home to knock them out of the Copa del Rey
Arsenal closed the gap on leaders Liverpool with a 2-1 Premier League victory at Nottingham Forest
Jarrod Bowen and Mohammed Kudus' second-half goals gave West Ham a 2-0 win over Manchester United in the Premier League's early game on Saturday, as the Hammers briefly moved into the top six.
Manchester City and Arsenal closed in on Premier League leaders Liverpool with contrasting victories on Saturday as Manchester United's bubble was burst by Fulham.
Koopmeiners leads Atalanta past Milan into Coppa semis
Arsenal's Arteta wary of old foe Villa
A summary of Thursday's Europa League quarter-finals second-leg.
A round-up of Saturday's action in the Premier League.
Reach fifth round for first time in 10 years
IMAGES from the Premier League matches played on Saturday.
IMAGES from the Premier League matches played on Tuesday.
Tottenham Hotspur hammered 10-man Aston Villa 4-0 in the Premier League on Sunday thanks to four second-half goals, allowing them to close the gap with their Birmingham rivals to two points in the chase for Champions League football next season.
In a video that has now gone viral, Guardiola is seen giving young autograph hunters a dressing down for missing school and doing business reselling football memorabilia.
It is a first win in six games in all competitions for Liverpool.
A summary of Sunday's action in the Premier League.
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